GABRP

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Description

Gamma-aminobutyric acid type A receptor subunit pi

Tissue specificity

Tissue enhanced (breast, esophagus)

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

5 (170763350 - 170814047)

Ensembl ID

ENSG00000094755  (ver. 103.38)

Orthologs

Mouse Gabrp: ENSMUSG00000020159

UniProt

O00591

neXtProt

NX_O00591

Human splice variants
Mouse splice variants

Protein structure