NOX3

This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. [provided by RefSeq, May 2009]

Description

NADPH oxidase 3

Tissue specificity

Not detected

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

6 (155395368 - 155455839)

Ensembl ID

ENSG00000074771  (ver. 103.38)

Orthologs

Mouse Nox3: ENSMUSG00000023802

UniProt

Q9HBY0

neXtProt

NX_Q9HBY0

Human splice variants
Mouse splice variants

Protein structure