ACRBP

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

Description

Acrosin binding protein

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

12 (6638075 - 6647433)

Ensembl ID

ENSG00000111644  (ver. 103.38)

Orthologs

Mouse Acrbp: ENSMUSG00000072770

UniProt

Q8NEB7

neXtProt

NX_Q8NEB7

Human splice variants
Mouse splice variants

Protein structure