Tissue expression
Cell line expression
Protein structure
RASGRP1
RAS guanyl releasing protein 1CalDAG-GEFII, RASGRP
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | PA5-25750 | 1 references | Polyclonal |
WB
IHC
FC
OA |
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Abgent | AP5856c | Polyclonal |
WB
IHC
FC
|
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NSJ Bioreagents | RQ7733 | Polyclonal |
WB
EL
FC
|
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antibodies-online | ABIN2496244 | Polyclonal |
WB
EL
IHC
FC |
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Aviva Systems Biology | OAAB03257 | Polyclonal |
WB
EL
IHC
|
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