RASGRP1

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Description

RAS guanyl releasing protein 1

Tissue specificity

Tissue enhanced (brain, lymphoid tissue, retina)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

15 (38488103 - 38565575)

Ensembl ID

ENSG00000172575  (ver. 103.38)

Orthologs

Mouse Rasgrp1: ENSMUSG00000027347

UniProt

O95267

neXtProt

NX_O95267

Human splice variants
Mouse splice variants

Protein structure