Tissue expression
Cell line expression

MC1R

gene product
MSH-R 
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
More gene data

Antibodies

 

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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
377 antibodies from 34 providers.

Antibody properties

Applications

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
117 antibodies
OriGene
8 antibodies
Cusabio Biotech Co., Ltd
7 antibodies
GeneTex
4 antibodies
LifeSpan BioSciences, Inc.
36 antibodies
Invitrogen Antibodies
16 antibodies
Biorbyt
33 antibodies
Affinity Biosciences
2 antibodies
Aviva Systems Biology
4 antibodies
NovoPro Bioscience Inc.
4 antibodies
Proteintech Group
1 antibody
Boster Biological Technology
2 antibodies
Abgent
4 antibodies
Bioworld Technology, Inc
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Novus Biologicals
4 antibodies
RabMAbs
3 antibodies
Abnova Corporation
5 antibodies
FabGennix
6 antibodies
NSJ Bioreagents
1 antibody
St John's Laboratory
5 antibodies
Abbexa
11 antibodies
Enzo Life Sciences
2 antibodies
Creative Diagnostics
5 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
Acris Antibodies GmbH
1 antibody
Signalway Antibody LLC
1 antibody
United States Biological
40 antibodies
MyBioSource
5 antibodies
Creative Biolabs
19 antibodies
EMD Millipore
2 antibodies
Leading Biology
4 antibodies
RayBiotech, Inc.
2 antibodies