APBB2

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

amyloid beta (A4) precursor protein-binding, family B, member 2

Protein family

Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

4 (40810027 - 41216714)

Ensembl ID

ENSG00000163697  (ver. 84.38)

Orthologs

Mouse Apbb2: ENSMUSG00000029207

UniProt

Q92870

neXtProt

NX_Q92870

Human splice variants
Mouse splice variants