MSR1

gene product
CD204, SCARA1
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
659 antibodies from 31 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
GeneTex
17 antibodies
Novus Biologicals
67 antibodies
Atlas Antibodies
1 antibody
R&D Systems
25 antibodies
Abnova Corporation
9 antibodies
Biorbyt
30 antibodies
Affinity Biosciences
1 antibody
Aviva Systems Biology
16 antibodies
antibodies-online
103 antibodies
LifeSpan BioSciences, Inc.
121 antibodies
Acris Antibodies GmbH
11 antibodies
OriGene
126 antibodies
Invitrogen Antibodies
12 antibodies
Bioworld Technology, Inc
1 antibody
St John's Laboratory
3 antibodies
Abgent
3 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Diagnostics
5 antibodies
BioLegend
7 antibodies
Sino Biological Inc.
7 antibodies
MyBioSource
6 antibodies
GenWay
3 antibodies
EMD Millipore
1 antibody
United States Biological
52 antibodies
Creative Biolabs
8 antibodies
Sigma-Aldrich
2 antibodies
RabMAbs
1 antibody
Abbexa
3 antibodies
ProSci
1 antibody