VAV1

gene product
VAV
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
703 antibodies from 38 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
262 antibodies
Biorbyt
37 antibodies
Invitrogen Antibodies
6 antibodies
Novus Biologicals
25 antibodies
Affinity Biosciences
4 antibodies
GeneTex
10 antibodies
NovoPro Bioscience Inc.
6 antibodies
Abnova Corporation
7 antibodies
R&D Systems
3 antibodies
Atlas Antibodies
1 antibody
Proteintech Group
1 antibody
Abgent
7 antibodies
LifeSpan BioSciences, Inc.
92 antibodies
OriGene
15 antibodies
Acris Antibodies GmbH
9 antibodies
Aviva Systems Biology
8 antibodies
SignalChem
1 antibody
Bioworld Technology, Inc
4 antibodies
Signalway Antibody LLC
3 antibodies
Cell Signaling Technology, Inc
2 antibodies
Boster Biological Technology
3 antibodies
Bethyl Laboratories
1 antibody
RabMAbs
5 antibodies
Abbkine Scientific Co.Ltd.
6 antibodies
Creative Biolabs
30 antibodies
Arigo
1 antibody
St John's Laboratory
9 antibodies
ProSci
3 antibodies
Abbexa
1 antibody
United States Biological
96 antibodies
MyBioSource
7 antibodies
Sigma-Aldrich
5 antibodies
Creative Diagnostics
2 antibodies
RayBiotech, Inc.
1 antibody
GenWay
3 antibodies
EMD Millipore
2 antibodies
Exalpha Biologicals, Inc.
1 antibody