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Protein structure
TRIB2
Tribbles pseudokinase 2GS3955, TRB2
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Top validated antibodies |
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| Novus Biologicals |  H00028951-M04 |
4 references | Monoclonal |
WB
EL
ICC
IHC
BN
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| Invitrogen Antibodies | MA5-24942 |
1 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| LSBio | LS-C114609 |
Monoclonal |
WB
ICC
IHC
|
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| Abnova Corporation | H00028951-M04 |
3 references | Monoclonal |
WB
EL
IHC
|
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| Proteintech Group | 15359-1-AP |
2 references | Polyclonal |
WB
EL
IHC
|
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