Tissue expression
Cell line expression
Protein structure
TRIB2
Tribbles pseudokinase 2GS3955, TRB2
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Top validated antibodies |
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Novus Biologicals | H00028951-M04 | 4 references | Monoclonal |
WB
EL
ICC
IHC
BN
|
|
Invitrogen Antibodies | MA5-24942 | 1 references | Monoclonal |
WB
ICC
IHC
FC
OA
|
|
Abnova Corporation | H00028951-M04 | 3 references | Monoclonal |
WB
EL
IHC
|
|
Proteintech Group | 15359-1-AP | 2 references | Polyclonal |
WB
EL
IHC
|
|
GeneTex | GTX83495 | Monoclonal |
WB
ICC
IHC
FC |
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