PDE8A

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Description

phosphodiesterase 8A

Protein family

Enzymes, FDA approved drug targets, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

15:q25.3 (84980440 - 85139145)

Ensembl ID

ENSG00000073417  (ver. 84.38)

Orthologs

Mouse Pde8a: ENSMUSG00000025584

UniProt

O60658

neXtProt

NX_O60658

Human splice variants
Mouse splice variants