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COL25A1
Collagen type XXV alpha 1 chainThis gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Top validated antibodies |
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| antibodies-online |  ABIN2036091 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A08068-1 |
Polyclonal |
WB
EL
ICC
IHC
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| Cusabio Biotech Co., Ltd | CSB-PA070029 |
Polyclonal |
WB
EL
ICC
IHC
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| Acris Antibodies GmbH | AP17224PU-N |
Polyclonal |
WB
EL
IHC
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| Affinity Biosciences | DF3556 |
Polyclonal |
WB
EL
ICC
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