Tissue expression
Cell line expression
Protein structure
RBBP8
RB binding protein 8, endonucleaseCOM1, CtIP, RIM, SCKL2
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
GeneTex | ![]() |
6 references | Monoclonal |
|
|
Novus Biologicals | ![]() |
3 references | Monoclonal |
|
|
Biorbyt | ![]() |
Polyclonal |
|
||
Proteintech Group | ![]() |
4 references | Polyclonal |
|
|
Boster Biological Technology | ![]() |
Polyclonal |
|