Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
UBE2D2
Ubiquitin conjugating enzyme E2 D2UBC4, UbcH5B
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Top validated antibodies |
|||||
| antibodies-online |  ABIN393745 |
5 references | Monoclonal |
WB
EL
IHC
|
|
| Novus Biologicals | H00007322-M02 |
1 references | Monoclonal |
WB
EL
IHC
|
|
| LSBio | LS-B5548 |
Monoclonal |
WB
EL
IHC
|
||
| Proteintech Group | 28328-1-AP |
1 references | Polyclonal |
WB
EL
IHC
|
|
| Acris Antibodies GmbH | AM31013PU-N |
Monoclonal |
WB
EL
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider