Tissue expression
Cell line expression
Protein structure

PSMC1

Proteasome 26S subunit, ATPase 1
p56, S4 
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
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232 antibodies from 33 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
5 antibodies
Atlas Antibodies
1 antibody
Proteintech Group
1 antibody
Biorbyt
54 antibodies
Enzo Life Sciences
9 antibodies
Abnova Corporation
2 antibodies
Arigo
1 antibody
antibodies-online
52 antibodies
Invitrogen Antibodies
13 antibodies
Cusabio Biotech Co., Ltd
3 antibodies
Bethyl Laboratories
2 antibodies
ProSci
1 antibody
OriGene
3 antibodies
GeneTex
1 antibody
FineTest Biotech
1 antibody
NovoPro Bioscience Inc.
1 antibody
Acris Antibodies GmbH
1 antibody
St John's Laboratory
1 antibody
Aviva Systems Biology
2 antibodies
Creative Biolabs
3 antibodies
Abgent
2 antibodies
Bioworld Technology, Inc
1 antibody
MyBioSource
1 antibody
Abbexa
7 antibodies
Leading Biology
2 antibodies
Affinity Biosciences
1 antibody
Boster Biological Technology
1 antibody
United States Biological
12 antibodies
Creative Diagnostics
4 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
EMD Millipore
1 antibody