Tissue expression
Cell line expression

F2

gene product
 
This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]
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1171 antibodies from 41 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
94 antibodies
Proteintech Group
3 antibodies
Abnova Corporation
18 antibodies
Boster Biological Technology
4 antibodies
LifeSpan BioSciences, Inc.
255 antibodies
Aviva Systems Biology
6 antibodies
antibodies-online
322 antibodies
Cusabio Biotech Co., Ltd
10 antibodies
R&D Systems
3 antibodies
Affinity Biosciences
1 antibody
OriGene
15 antibodies
Bioworld Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
10 antibodies
Invitrogen Antibodies
32 antibodies
GeneTex
16 antibodies
NSJ Bioreagents
4 antibodies
Acris Antibodies GmbH
7 antibodies
Abgent
5 antibodies
Atlas Antibodies
2 antibodies
Santa Cruz Biotechnology
1 antibody
Biorbyt
50 antibodies
Abbkine Scientific Co.Ltd.
3 antibodies
Green Mountain Antibodies
5 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Creative Diagnostics
22 antibodies
Abbexa
13 antibodies
RabMAbs
3 antibodies
ProSci
2 antibodies
United States Biological
28 antibodies
Molecular Innovations
18 antibodies
MyBioSource
28 antibodies
Abbiotec
3 antibodies
RayBiotech, Inc.
1 antibody
Creative Biolabs
103 antibodies
GenWay
13 antibodies
Enzo Life Sciences
2 antibodies
EMD Millipore
2 antibodies
Leading Biology
2 antibodies
MilliporeSigma / Merck KGaA
6 antibodies
Sino Biological Inc.
1 antibody