FHOD3

gene product
FHOS2, FLJ22297, FLJ22717, KIAA1695
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
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AntibodyRefsTypeWBELICCIPIHCFC
Acris Antibodies GmbH
1 antibody
Novus Biologicals
3 antibodies
Abnova Corporation
2 antibodies
Atlas Antibodies
2 antibodies
antibodies-online
21 antibodies
Biorbyt
5 antibodies
GeneTex
1 antibody
Invitrogen Antibodies
3 antibodies
LifeSpan BioSciences, Inc.
1 antibody
Boster Biological Technology
1 antibody
Sigma-Aldrich
3 antibodies
Creative Diagnostics
1 antibody
United States Biological
1 antibody