PCSK2

gene product
NEC2, PC2, SPC2
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
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189 antibodies from 29 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
7 antibodies
NSJ Bioreagents
3 antibodies
Biorbyt
14 antibodies
Abgent
2 antibodies
OriGene
3 antibodies
antibodies-online
75 antibodies
Invitrogen Antibodies
7 antibodies
R&D Systems
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
Aviva Systems Biology
4 antibodies
Enzo Life Sciences
1 antibody
Boster Biological Technology
2 antibodies
ProSci
2 antibodies
Atlas Antibodies
1 antibody
Cell Signaling Technology, Inc
1 antibody
LifeSpan BioSciences, Inc.
20 antibodies
GeneTex
2 antibodies
RabMAbs
3 antibodies
MyBioSource
4 antibodies
Proteintech Group
1 antibody
Abnova Corporation
3 antibodies
Creative Biolabs
8 antibodies
Creative Diagnostics
3 antibodies
Acris Antibodies GmbH
5 antibodies
GenWay
3 antibodies
EMD Millipore
1 antibody
St John's Laboratory
1 antibody
United States Biological
5 antibodies
Sigma-Aldrich
4 antibodies