NFATC4

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Description

Nuclear factor of activated T cells 4

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

14 (24365673 - 24379604)

Ensembl ID

ENSG00000100968  (ver. 103.38)

Orthologs

Mouse Nfatc4: ENSMUSG00000023411

UniProt

Q14934

neXtProt

NX_Q14934

Human splice variants
Mouse splice variants

Protein structure