CHRNA7

gene product
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
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antibodies-online
100 antibodies
Novus Biologicals
5 antibodies
Biorbyt
28 antibodies
LifeSpan BioSciences, Inc.
51 antibodies
NovoPro Bioscience Inc.
5 antibodies
GeneTex
2 antibodies
St John's Laboratory
2 antibodies
Antibodies.com
1 antibody
Acris Antibodies GmbH
6 antibodies
Proteintech Group
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10 antibodies
FabGennix
3 antibodies
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1 antibody
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6 antibodies
Aviva Systems Biology
3 antibodies
BioLegend (formerly Covance Antibody Products)
2 antibodies
Abgent
3 antibodies
Abbiotec
1 antibody
Bioworld Technology, Inc
1 antibody
ProSci
3 antibodies
MyBioSource
4 antibodies
Invitrogen Antibodies
1 antibody
EMD Millipore
2 antibodies
RayBiotech, Inc.
1 antibody
United States Biological
25 antibodies
GenWay
4 antibodies
Sigma-Aldrich
3 antibodies
Abbexa
1 antibody