PLEK2

The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]

Description

Pleckstrin 2

Tissue specificity

Tissue enhanced (adrenal gland)

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (67386984 - 67412167)

Ensembl ID

ENSG00000100558  (ver. 103.38)

Orthologs

Mouse Plek2: ENSMUSG00000021118

UniProt

Q9NYT0

neXtProt

NX_Q9NYT0

Human splice variants
Mouse splice variants

Protein structure