PDLIM2

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Description

PDZ and LIM domain 2

Tissue specificity

Low tissue specificity

Subcell location

Actin filaments, Focal adhesion sites

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (22578279 - 22598025)

Ensembl ID

ENSG00000120913  (ver. 103.38)

Orthologs

Mouse Pdlim2: ENSMUSG00000022090

UniProt

Q96JY6

neXtProt

NX_Q96JY6

Human splice variants
Mouse splice variants

Protein structure