PRKG2

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]

Description

Protein kinase cGMP-dependent 2

Tissue specificity

Tissue enhanced (intestine, prostate)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4:q21.21 (81087370 - 81215117)

Ensembl ID

ENSG00000138669  (ver. 103.38)

Orthologs

Mouse Prkg2: ENSMUSG00000029334

UniProt

Q13237

neXtProt

NX_Q13237

Human splice variants
Mouse splice variants