IL2RB

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

Description

Interleukin 2 receptor subunit beta

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue, placenta)

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

22 (37125843 - 37175054)

Ensembl ID

ENSG00000100385  (ver. 103.38)

Orthologs

Mouse Il2rb: ENSMUSG00000068227

UniProt

P14784

neXtProt

NX_P14784

Human splice variants
Mouse splice variants

Protein structure