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Protein structure
MALT1
MALT1 paracaspaseMLT, PCASP1
This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]
Top validated antibodies |
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| Proteintech Group |  11660-1-AP |
6 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NBP2-29430 |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | 11660-1-AP |
Polyclonal |
WB
ICC
IHC
FC
|
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| OriGene | AM50100PU-S |
Monoclonal |
WB
ICC
IP
IHC
FC
|
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| LSBio | LS-C340240 |
Monoclonal |
WB
IHC
|
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