ARFGEF1

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]

Description

ADP ribosylation factor guanine nucleotide exchange factor 1

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

8:q13.2 (67173511 - 67343781)

Ensembl ID

ENSG00000066777  (ver. 99.38)

Orthologs

Mouse Arfgef1: ENSMUSG00000067851

UniProt

Q9Y6D6

neXtProt

NX_Q9Y6D6

Human splice variants
Mouse splice variants