RUFY3

This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Description

RUN and FYVE domain containing 3

Tissue specificity

Tissue enhanced (retina)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (70704204 - 70808619)

Ensembl ID

ENSG00000018189  (ver. 103.38)

Orthologs

Mouse Rufy3: ENSMUSG00000029291

UniProt

Q7L099

neXtProt

NX_Q7L099

Human splice variants
Mouse splice variants

Protein structure