PCSK1

gene product
NEC1, PC1, PC3, SPC3
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]
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168 antibodies from 28 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
36 antibodies
Novus Biologicals
5 antibodies
Acris Antibodies GmbH
4 antibodies
Abnova Corporation
3 antibodies
LifeSpan BioSciences, Inc.
45 antibodies
NovoPro Bioscience Inc.
7 antibodies
GeneTex
3 antibodies
Abgent
3 antibodies
Aviva Systems Biology
2 antibodies
OriGene
2 antibodies
NSJ Bioreagents
1 antibody
Invitrogen Antibodies
4 antibodies
Biorbyt
9 antibodies
Boster Biological Technology
1 antibody
ProSci
3 antibodies
Creative Biolabs
4 antibodies
Creative Diagnostics
4 antibodies
Atlas Antibodies
1 antibody
RayBiotech, Inc.
1 antibody
United States Biological
15 antibodies
Sigma-Aldrich
3 antibodies
Cell Signaling Technology, Inc
1 antibody
St John's Laboratory
1 antibody
MyBioSource
4 antibodies
EMD Millipore
1 antibody
GenWay
2 antibodies
Sino Biological Inc.
2 antibodies
Enzo Life Sciences
1 antibody