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ZYX
ZyxinFocal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| antibodies-online |  ABIN395405 |
5 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | H00007791-M01 |
5 references | Monoclonal |
WB
EL
ICC
IP
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| Abnova Corporation | H00007791-M01 |
2 references | Monoclonal |
WB
EL
ICC
IP
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| Proteintech Group | 60254-1-Ig |
5 references | Monoclonal |
WB
EL
ICC
IHC
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| Atlas Antibodies | HPA004835 |
11 references | Polyclonal |
WB
ICC
IHC
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