RAB21

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

Description

RAB21, member RAS oncogene family

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

12:q21.1 (71754863 - 71800286)

Ensembl ID

ENSG00000080371  (ver. 99.38)

Orthologs

Mouse Rab21: ENSMUSG00000020132

UniProt

Q9UL25

neXtProt

NX_Q9UL25

Human splice variants
Mouse splice variants