ASB2

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Description

Ankyrin repeat and SOCS box containing 2

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Nucleoplasm, Nucleoli fibrillar center, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

14 (93934166 - 93976739)

Ensembl ID

ENSG00000100628  (ver. 103.38)

Orthologs

Mouse Asb2: ENSMUSG00000021200

UniProt

Q96Q27

neXtProt

NX_Q96Q27

Human splice variants
Mouse splice variants

Protein structure