Tissue expression
Cell line expression
Protein structure
NR1I2
Nuclear receptor subfamily 1 group I member 2BXR, ONR1, PAR2, PXR, SXR
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | PA5-72551 | 1 references | Polyclonal |
WB
ICC
IHC
FC
OA
|
|
GeneTex | GTX81102 | 1 references | Polyclonal |
WB
ICC
IHC
FC |
|
Boster Biological Technology | A01133-3 | 1 references | Polyclonal |
WB
EL
IHC
FC |
|
antibodies-online | ABIN2842413 | 1 references | Polyclonal |
WB
ICC
IHC
FC |
|
Abgent | AP8674c | Polyclonal |
WB
ICC
IHC
FC |
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