KCNJ10

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

Description

Potassium inwardly rectifying channel subfamily J member 10

Tissue specificity

Group enriched (brain, kidney, retina)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

1:q23.2 (159998651 - 160070160)

Ensembl ID

ENSG00000177807  (ver. 103.38)

Orthologs

Mouse Kcnj10: ENSMUSG00000044708

UniProt

P78508

neXtProt

NX_P78508

Human splice variants
Mouse splice variants