P2RY2

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

Description

Purinergic receptor P2Y2

Tissue specificity

Tissue enhanced (esophagus, skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

11 (73218281 - 73242427)

Ensembl ID

ENSG00000175591  (ver. 103.38)

Orthologs

Mouse P2ry2: ENSMUSG00000032860

UniProt

P41231

neXtProt

NX_P41231

Human splice variants
Mouse splice variants

Protein structure