P2RY6

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Description

Pyrimidinergic receptor P2Y6

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

11 (73264498 - 73305103)

Ensembl ID

ENSG00000171631  (ver. 103.38)

Orthologs

Mouse P2ry6: ENSMUSG00000048779

UniProt

Q15077

neXtProt

NX_Q15077

Human splice variants
Mouse splice variants

Protein structure