KDM5A

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

Description

lysine (K)-specific demethylase 5A

Protein family

Cancer-related genes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014), Transcription factors

Chromosome

12:p13.33 (280129 - 389454)

Ensembl ID

ENSG00000073614  (ver. 84.38)

Orthologs

Mouse Kdm5a: ENSMUSG00000030180

UniProt

P29375

neXtProt

NX_P29375

Human splice variants
Mouse splice variants