ERCC2
gene productEM9, MAG, MGC102762, MGC126218, MGC126219, TFIIH, XPD
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Featured antibodies
 Atlas Antibodies |
 HPA038057 |
0 references | Polyclonal |
WB
IHC
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 MilliporeSigma / Merck KGaA |
WH0002068M1 |
0 references | Monoclonal |
EL
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