Tissue expression
Cell line expression
Protein structure
SAP18
Sin3A associated protein 182HOR0202, MGC27131, SAP18p
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Top validated antibodies |
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Proteintech Group | ![]() |
1 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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NSJ Bioreagents | ![]() |
Polyclonal |
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NovoPro Bioscience Inc. | ![]() |
Polyclonal |
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Biorbyt | ![]() |
Polyclonal |
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