Tissue expression
Cell line expression
Protein structure
LITAF
Lipopolysaccharide induced TNF factorFLJ38636, PIG7, SIMPLE, TP53I7
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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Proteintech Group | 16797-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP
IHC
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Invitrogen Antibodies | 16797-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
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Atlas Antibodies | HPA006960 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Novus Biologicals | NBP1-83473 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
GeneTex | GTX109173 | Polyclonal |
WB
IP
IHC
ChIP |
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider