Tissue expression
Cell line expression
Protein structure
IBTK
Inhibitor of Bruton tyrosine kinaseBTBD26, BTKI, DKFZP564B116
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Top validated antibodies |
|||||
Novus Biologicals | ![]() |
3 references | Polyclonal |
|
|
antibodies-online | ![]() |
2 references | Polyclonal |
|
|
LSBio | ![]() |
Polyclonal |
|
||
Acris Antibodies GmbH | ![]() |
Polyclonal |
|
||
OriGene | ![]() |
Polyclonal |
|