Tissue expression
Cell line expression
Protein structure
PDCD10
Programmed cell death 10CCM3, TFAR15
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 10294-2-AP | 12 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
NovoPro Bioscience Inc. | 109067 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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Invitrogen Antibodies | 10294-2-AP | Polyclonal |
WB
IHC
OA
|
||
antibodies-online | ABIN1874056 | Polyclonal |
WB
ICC
IP
IHC |
||
Affinity Biosciences | DF7080 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider