XRCC4

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]

Description

X-ray repair complementing defective repair in Chinese hamster cells 4

Protein family

Cancer-related genes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

5:q14.2 (83077498 - 83353787)

Ensembl ID

ENSG00000152422  (ver. 84.38)

Orthologs

Mouse Xrcc4: ENSMUSG00000021615

UniProt

Q13426

neXtProt

NX_Q13426

Human splice variants
Mouse splice variants