POU2F3

This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Description

POU class 2 homeobox 3

Tissue specificity

Tissue enriched (skin)

Subcell location

Nucleoplasm, Nucleoli, Nuclear bodies, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

11 (120236640 - 120319945)

Ensembl ID

ENSG00000137709  (ver. 103.38)

Orthologs

Mouse Pou2f3: ENSMUSG00000032015

UniProt

Q9UKI9

neXtProt

NX_Q9UKI9

Human splice variants
Mouse splice variants

Protein structure