CLDN16

gene product
HOMG3, PCLN1
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]
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198 antibodies from 24 providers.

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Antibody
antibodies-online
65 antibodies
Invitrogen Antibodies
3 antibodies
Biorbyt
9 antibodies
Novus Biologicals
3 antibodies
OriGene
3 antibodies
Abgent
1 antibody
Acris Antibodies GmbH
1 antibody
Aviva Systems Biology
3 antibodies
LifeSpan BioSciences, Inc.
48 antibodies
Abnova Corporation
3 antibodies
Proteintech Group
1 antibody
GeneTex
2 antibodies
MyBioSource
3 antibodies
Atlas Antibodies
1 antibody
United States Biological
15 antibodies
ProSci
2 antibodies
Creative Diagnostics
5 antibodies
Boster Biological Technology
1 antibody
St John's Laboratory
1 antibody
Creative Biolabs
6 antibodies
Sigma-Aldrich
3 antibodies
GenWay
2 antibodies
Abbexa
2 antibodies