WIPI1

This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Description

WD repeat domain, phosphoinositide interacting 1

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (68420948 - 68457513)

Ensembl ID

ENSG00000070540  (ver. 103.38)

Orthologs

Mouse Wipi1: ENSMUSG00000041895

UniProt

Q5MNZ9

neXtProt

NX_Q5MNZ9

Human splice variants
Mouse splice variants

Protein structure