SEMA4A

gene product
CORD10, FLJ12287, SEMAB, SemB
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
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antibodies-online
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1 antibody
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1 antibody
Creative Biolabs
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MyBioSource
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Boster Biological Technology
1 antibody
ProSci
1 antibody
St John's Laboratory
1 antibody
Creative Diagnostics
4 antibodies
Sino Biological Inc.
2 antibodies
GenWay
1 antibody
Sigma-Aldrich
2 antibodies