Tissue expression
Cell line expression
Protein structure
PRMT6
Protein arginine methyltransferase 6FLJ10559, HRMT1L6
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
Top validated antibodies |
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Proteintech Group | 15395-1-AP | 11 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Invitrogen Antibodies | 15395-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
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LSBio | LS-C393488 | Monoclonal |
WB
ICC
IHC
|
||
Novus Biologicals | NB110-40713 | 2 references | Polyclonal |
WB
IP
IHC
|
|
antibodies-online | ABIN1998696 | 3 references | Polyclonal |
WB
EL
IP
|
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Supportive data in Antibodypedia
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Recommended by provider