Tissue expression
Cell line expression

ANG

gene product
RAA1, RNASE5 
The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]
More gene data

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Antigen sequence

Conjugate

Epitope

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
467 antibodies from 34 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
48 antibodies
Proteintech Group
2 antibodies
LifeSpan BioSciences, Inc.
114 antibodies
GeneTex
6 antibodies
R&D Systems
5 antibodies
Invitrogen Antibodies
13 antibodies
antibodies-online
138 antibodies
Biorbyt
14 antibodies
Boster Biological Technology
3 antibodies
Bioworld Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
Cusabio Biotech Co., Ltd
7 antibodies
Affinity Biosciences
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
OriGene
3 antibodies
Abnova Corporation
3 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
St John's Laboratory
4 antibodies
Acris Antibodies GmbH
3 antibodies
Abgent
3 antibodies
ProSci
1 antibody
NSJ Bioreagents
1 antibody
Absolute Antibody
7 antibodies
MyBioSource
12 antibodies
Creative Biolabs
21 antibodies
Abbexa
12 antibodies
Leading Biology
3 antibodies
United States Biological
24 antibodies
Creative Diagnostics
4 antibodies
EMD Millipore
2 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
Aviva Systems Biology
1 antibody
RayBiotech, Inc.
1 antibody
Rockland Immunochemicals, Inc.
1 antibody