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Protein structure
CENPJ
Centromere protein JBM032, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Top validated antibodies |
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| Proteintech Group |  11517-1-AP |
49 references | Polyclonal |
WB
EL
ICC
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| antibodies-online | ABIN394394 |
5 references | Monoclonal |
WB
EL
IHC
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| Invitrogen Antibodies | MA5-22212 |
Monoclonal |
WB
EL
IP
OA
|
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| LSBio | LS-C133781 |
Monoclonal |
WB
EL
IHC
|
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| Novus Biologicals | H00055835-M02 |
Monoclonal |
WB
EL
IP
|
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