PRAME

This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Description

preferentially expressed antigen in melanoma

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

22:q11.22 (22547701 - 22559361)

Ensembl ID

ENSG00000185686  (ver. 98.38)

Orthologs

-

UniProt

P78395

neXtProt

NX_P78395

Human splice variants