MPL

gene product
CD110, TPOR
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
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201 antibodies from 29 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Biorbyt
9 antibodies
antibodies-online
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Novus Biologicals
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GeneTex
2 antibodies
Acris Antibodies GmbH
1 antibody
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1 antibody
LifeSpan BioSciences, Inc.
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Affinity Biosciences
3 antibodies
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4 antibodies
Invitrogen Antibodies
3 antibodies
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2 antibodies
Abgent
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Boster Biological Technology
1 antibody
RabMAbs
2 antibodies
NSJ Bioreagents
1 antibody
Miltenyi Biotec
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Creative Biolabs
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MyBioSource
4 antibodies
St John's Laboratory
2 antibodies
Abiocode, Inc.
1 antibody
Cell Signaling Technology, Inc
1 antibody
EMD Millipore
1 antibody
United States Biological
2 antibodies
Sigma-Aldrich
2 antibodies
BioLegend
4 antibodies
Abbexa
3 antibodies
Creative Diagnostics
1 antibody